Abstract
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / metabolism*
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Animals
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Ethylmaleimide / pharmacology
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Heat-Shock Proteins / metabolism*
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Humans
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Kinetics
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Mitochondria / drug effects
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Mitochondria / metabolism*
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Neurospora / enzymology
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Protein Conformation*
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Proton-Translocating ATPases / metabolism*
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Tetrahydrofolate Dehydrogenase / metabolism*
Substances
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Heat-Shock Proteins
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Adenosine Triphosphate
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Tetrahydrofolate Dehydrogenase
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Proton-Translocating ATPases
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Ethylmaleimide