IFITM proteins-cellular inhibitors of viral entry

Se Smith; S Weston; P Kellam; M Marsh

doi:10.1016/j.coviro.2013.11.004

IFITM proteins-cellular inhibitors of viral entry

Curr Opin Virol. 2014 Feb:4:71-7. doi: 10.1016/j.coviro.2013.11.004. Epub 2014 Jan 28.

Authors

Se Smith¹, S Weston², P Kellam³, M Marsh⁴

Affiliations

¹ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
² MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
³ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK; MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: pk5@sanger.ac.uk.
⁴ MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: m.marsh@ucl.ac.uk.

Abstract

Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Membrane / immunology
Cell Membrane / metabolism
Host-Pathogen Interactions*
Humans
Interferons / immunology*
Interferons / metabolism*
Intracellular Membranes / immunology
Intracellular Membranes / metabolism
Membrane Proteins / metabolism*
Virus Internalization*
Viruses / immunology*

Substances

Membrane Proteins
Interferons

Abstract

Publication types

MeSH terms

Substances

Grants and funding