Comparison of splicing factor 3b inhibitors in human cells

Chembiochem. 2013 Jan 2;14(1):49-52. doi: 10.1002/cbic.201200558. Epub 2012 Nov 22.

Abstract

Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Exons / genetics
  • Genes, Reporter / genetics
  • HEK293 Cells
  • Humans
  • Introns / genetics
  • Luciferases, Firefly / genetics
  • Morpholines / pharmacology*
  • Pyrans / pharmacology*
  • RNA Splicing / drug effects*
  • Ribonucleoprotein, U2 Small Nuclear / antagonists & inhibitors*
  • Ribonucleoprotein, U2 Small Nuclear / metabolism
  • Triose-Phosphate Isomerase / genetics

Substances

  • Morpholines
  • Pyrans
  • Ribonucleoprotein, U2 Small Nuclear
  • meayamycin B
  • splicing factor 3a
  • Luciferases, Firefly
  • Triose-Phosphate Isomerase