Abstract
Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Exons / genetics
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Genes, Reporter / genetics
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HEK293 Cells
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Humans
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Introns / genetics
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Luciferases, Firefly / genetics
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Morpholines / pharmacology*
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Pyrans / pharmacology*
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RNA Splicing / drug effects*
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Ribonucleoprotein, U2 Small Nuclear / antagonists & inhibitors*
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Ribonucleoprotein, U2 Small Nuclear / metabolism
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Triose-Phosphate Isomerase / genetics
Substances
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Morpholines
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Pyrans
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Ribonucleoprotein, U2 Small Nuclear
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meayamycin B
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splicing factor 3a
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Luciferases, Firefly
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Triose-Phosphate Isomerase