The birth of the Epitranscriptome: deciphering the function of RNA modifications

Genome Biol. 2012 Oct 31;13(10):175. doi: 10.1186/gb-2012-13-10-175.

Abstract

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Adenosine / metabolism*
  • Animals
  • Epigenomics / methods*
  • HEK293 Cells
  • Hep G2 Cells
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • RNA / metabolism*
  • RNA Processing, Post-Transcriptional*
  • Transcriptome

Substances

  • 3' Untranslated Regions
  • RNA
  • Adenosine