Abstract
Adenosine monophosphate-activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.
© 2012 The Authors Journal compilation © 2012 by the Molecular Biology Society of Japan/Wiley Publishing Ltd.
MeSH terms
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AMP-Activated Protein Kinase Kinases
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AMP-Activated Protein Kinases / genetics
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AMP-Activated Protein Kinases / physiology*
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Animals
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Caenorhabditis elegans / enzymology
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Caenorhabditis elegans / physiology
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Cell Movement
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Cell Polarity*
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Cell Shape
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Drosophila / enzymology
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Drosophila / genetics
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Drosophila / physiology
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology*
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Gene Expression Regulation, Enzymologic*
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Mammals / genetics
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Mammals / physiology
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / physiology
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Microtubules / physiology
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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Phosphorylation
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Protein Kinases / genetics
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Protein Kinases / physiology*
Substances
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Drosophila Proteins
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Microtubule-Associated Proteins
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Neoplasm Proteins
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cytoplasmic linker protein 170
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Protein Kinases
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LKB1 protein, Drosophila
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AMP-Activated Protein Kinase Kinases
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AMP-Activated Protein Kinases