Abstract
During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Aurora Kinases
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Cell Cycle Proteins* / metabolism
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Cell Division / physiology*
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Cytokinesis / physiology
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Endosomal Sorting Complexes Required for Transport / metabolism*
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Endosomes / physiology
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Nuclear Pore / physiology
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Polo-Like Kinase 1
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Protein Serine-Threonine Kinases* / metabolism
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Protein Transport* / physiology
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Proto-Oncogene Proteins* / metabolism
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Signal Transduction
Substances
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Cell Cycle Proteins
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Endosomal Sorting Complexes Required for Transport
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Proto-Oncogene Proteins
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Aurora Kinases
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Protein Serine-Threonine Kinases