Napyradiomycin A1, an inhibitor of mitochondrial complexes I and II

J Antibiot (Tokyo). 2012 Apr;65(4):211-4. doi: 10.1038/ja.2011.138. Epub 2012 Jan 18.

Authors

Kohta Yamamoto¹, Etsu Tashiro, Keiichiro Motohashi, Haruo Seto, Masaya Imoto

Affiliation

¹ Chemical Biology Laboratory, Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama City, Japan.

PMID: 22252199
DOI: 10.1038/ja.2011.138

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / metabolism
Cell Line, Tumor
Cell Survival / drug effects
Electron Transport Complex I / antagonists & inhibitors*
Electron Transport Complex I / metabolism
Electron Transport Complex II / antagonists & inhibitors*
Electron Transport Complex II / metabolism
Humans
Mitochondria / drug effects*
Mitochondria / metabolism
Naphthoquinones / pharmacology

Substances

Naphthoquinones
napyradiomycin A1
Adenosine Triphosphate
Electron Transport Complex II
Electron Transport Complex I