Abstract
Time shift:
A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Casein Kinase Idelta / chemistry
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Casein Kinase Idelta / metabolism
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Cell Line, Tumor
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Circadian Rhythm / drug effects*
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Humans
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Luminescent Measurements
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Period Circadian Proteins / chemistry*
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Period Circadian Proteins / metabolism
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Phosphorylation / drug effects
Substances
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Period Circadian Proteins
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Casein Kinase Idelta