Abstract
The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Evolution, Molecular
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Guanine Nucleotide Dissociation Inhibitors / chemistry
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Guanine Nucleotide Dissociation Inhibitors / genetics
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Guanine Nucleotide Dissociation Inhibitors / metabolism*
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Humans
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Membrane Microdomains / metabolism
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Metabolic Networks and Pathways
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Models, Biological
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Models, Molecular
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Molecular Chaperones / metabolism
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Multiprotein Complexes
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Neoplasms / metabolism
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Phosphorylation
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Phylogeny
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Protein Interaction Domains and Motifs
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rho GTP-Binding Proteins / chemistry
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rho GTP-Binding Proteins / metabolism*
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rho Guanine Nucleotide Dissociation Inhibitor alpha
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rho-Specific Guanine Nucleotide Dissociation Inhibitors
Substances
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ARHGDIA protein, human
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Guanine Nucleotide Dissociation Inhibitors
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Molecular Chaperones
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Multiprotein Complexes
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rho Guanine Nucleotide Dissociation Inhibitor alpha
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rho-Specific Guanine Nucleotide Dissociation Inhibitors
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rho GTP-Binding Proteins