Living the high life: high-altitude adaptation

Genome Biol. 2010;11(9):133. doi: 10.1186/gb-2010-11-9-133. Epub 2010 Sep 10.

Abstract

Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acclimatization / genetics*
  • Altitude Sickness / genetics
  • Altitude*
  • Environment
  • Genetic Variation
  • Hemoglobins / analysis
  • Humans
  • Hypoxia-Inducible Factor 1 / genetics*
  • Polymorphism, Single Nucleotide
  • South America
  • Tibet

Substances

  • Hemoglobins
  • Hypoxia-Inducible Factor 1