Abstract
Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immunocompromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adaptive Immunity
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Animals
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Candida albicans / immunology*
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Candidiasis / immunology*
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Candidiasis / metabolism
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Cell Line
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Host-Pathogen Interactions
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Humans
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Immunity, Innate
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Interleukin-17 / metabolism*
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Interleukin-22
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Interleukin-23 / metabolism
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Interleukins / metabolism
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Models, Animal
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Mucous Membrane / immunology*
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Mucous Membrane / metabolism
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Mucous Membrane / microbiology
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Interleukin-17
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Interleukin-23
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Interleukins