Abstract
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient beta-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Caenorhabditis elegans Proteins / chemistry
-
Caenorhabditis elegans Proteins / classification
-
Caenorhabditis elegans Proteins / genetics
-
Caenorhabditis elegans Proteins / metabolism
-
Eukaryotic Cells / metabolism*
-
Eukaryotic Initiation Factors / chemistry
-
Eukaryotic Initiation Factors / classification
-
Eukaryotic Initiation Factors / genetics
-
Eukaryotic Initiation Factors / metabolism*
-
Exosomes / metabolism
-
Gene Expression Regulation / genetics
-
Gene Expression Regulation / physiology
-
Heat-Shock Proteins / chemistry
-
Heat-Shock Proteins / classification
-
Heat-Shock Proteins / genetics
-
Heat-Shock Proteins / metabolism*
-
Humans
-
Phylogeny
-
Protein Structure, Secondary
-
Repressor Proteins / chemistry
-
Repressor Proteins / classification
-
Repressor Proteins / genetics
-
Repressor Proteins / metabolism
-
Y-Box-Binding Protein 1 / chemistry
-
Y-Box-Binding Protein 1 / classification
-
Y-Box-Binding Protein 1 / genetics
-
Y-Box-Binding Protein 1 / metabolism
Substances
-
Caenorhabditis elegans Proteins
-
Eukaryotic Initiation Factors
-
Heat-Shock Proteins
-
LIN-28 protein, C elegans
-
Repressor Proteins
-
Y-Box-Binding Protein 1