Abstract
The genes encoding a gamma delta T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the TIa locus have been inserted into the mouse germ line. In mice that do not express the TIa-encoded determinant, transgenic gamma delta T cells are a functional component of the CD4-CD8- 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the TIa-encoded determinant, there are no transgenic gamma delta T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic gamma delta T-cell receptor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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CD4-Positive T-Lymphocytes / immunology
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Cloning, Molecular
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Gene Expression
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H-2 Antigens / immunology
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Histocompatibility Antigen H-2D
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Histocompatibility Antigens Class I / immunology
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Immune Tolerance
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Leukocyte Count
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Transgenic
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Molecular Sequence Data
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / immunology*
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Spleen / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Regulatory / immunology
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Thymus Gland / cytology*
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Thymus Gland / immunology
Substances
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H-2 Antigens
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Histocompatibility Antigen H-2D
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Histocompatibility Antigens Class I
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Receptors, Antigen, T-Cell