Abstract
The Wnt/beta-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.
(c) 2009 Wiley-Liss, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Axin Protein
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Embryonic Development / physiology*
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Gene Expression Regulation / physiology*
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Homeostasis / physiology*
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Models, Biological
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Phosphorylation
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Protein Kinases / metabolism*
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Repressor Proteins / metabolism
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Signal Transduction / physiology*
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Wnt Proteins / metabolism*
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beta Catenin / metabolism*
Substances
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Axin Protein
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Repressor Proteins
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Wnt Proteins
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beta Catenin
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Protein Kinases