Abstract
Spinal muscular atrophy (SMA) is an important cause of death in children and SMA type I, also known as Werdnig-Hoffman disease, is the most severe form of this disease. We report 2 cases of infants with SMA I in whom a distal necrosis developed, a feature not previously reported. Poor perfusion, autonomic dysfunction, and position-dependent factors may all play a role in the development of this complication.
MeSH terms
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Anti-Infective Agents, Local / therapeutic use
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Anticoagulants / therapeutic use
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Aspirin / therapeutic use
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Diosmin / therapeutic use
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Female
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Fingers / blood supply*
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Fingers / pathology*
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Heparin / therapeutic use
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Humans
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Infant
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Necrosis / drug therapy
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Necrosis / etiology
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Pentoxifylline / therapeutic use
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Platelet Aggregation Inhibitors / therapeutic use
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Spinal Muscular Atrophies of Childhood / complications*
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Toes / blood supply*
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Toes / pathology*
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Vasodilator Agents / therapeutic use
Substances
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Anti-Infective Agents, Local
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Anticoagulants
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Platelet Aggregation Inhibitors
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Vasodilator Agents
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Diosmin
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Heparin
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Aspirin
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Pentoxifylline