Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Benjamin M Hogan; Frank L Bos; Jeroen Bussmann; Merlijn Witte; Neil C Chi; Henricus J Duckers; Stefan Schulte-Merker

doi:10.1038/ng.321

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Nat Genet. 2009 Apr;41(4):396-8. doi: 10.1038/ng.321. Epub 2009 Mar 15.

Authors

Benjamin M Hogan¹, Frank L Bos, Jeroen Bussmann, Merlijn Witte, Neil C Chi, Henricus J Duckers, Stefan Schulte-Merker

Affiliation

¹ Hubrecht Institute-KNAW & University Medical Centre, Utrecht, The Netherlands.

PMID: 19287381
DOI: 10.1038/ng.321

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Substitution
Animals
Binding Sites
Calcium / metabolism
Cell Division
Cell Movement
Embryo, Nonmammalian / physiology
Embryonic Development
Epidermal Growth Factor / genetics*
Humans
Lymphangiogenesis / genetics*
Lymphatic Vessels / cytology
Lymphatic Vessels / embryology
Lymphatic Vessels / physiology*
Models, Animal
Mutation*
Vascular Endothelial Growth Factor C / genetics
Zebrafish

Substances

VEGFC protein, human
Vascular Endothelial Growth Factor C
Epidermal Growth Factor
Calcium