Abstract
The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cytosol / metabolism
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Endopeptidases / metabolism*
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Fructose-Bisphosphatase / isolation & purification
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Fructose-Bisphosphatase / metabolism*
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Kinetics
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Models, Biological
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Molecular Weight
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Mutation
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae / ultrastructure
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Vacuoles / metabolism*
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Vacuoles / ultrastructure
Substances
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Fructose-Bisphosphatase
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Endopeptidases