Abstract
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen Presentation / immunology*
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Bone Marrow Cells / drug effects
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Bone Marrow Cells / immunology
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Dendritic Cells / drug effects
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Dendritic Cells / immunology*
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Disease Models, Animal
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Female
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Hemeproteins / metabolism
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Hemeproteins / pharmacology
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Host-Parasite Interactions
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Lymphocyte Activation / immunology
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Malaria / blood
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Malaria / immunology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Transgenic
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Phagocytosis
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Pigments, Biological / metabolism
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Pigments, Biological / pharmacology
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Plasmodium chabaudi / immunology*
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Protein Sorting Signals / drug effects
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Protein Sorting Signals / physiology*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Hemeproteins
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Pigments, Biological
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Protein Sorting Signals
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hemozoin