RNA-quality control by the exosome

Nat Rev Mol Cell Biol. 2006 Jul;7(7):529-39. doi: 10.1038/nrm1964.

Abstract

The exosome complex of 3'-->5' exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.

Publication types

  • Review

MeSH terms

  • Animals
  • Archaeal Proteins / chemistry
  • Archaeal Proteins / genetics
  • Archaeal Proteins / metabolism
  • Cell Nucleus / genetics
  • Enzyme Activation
  • Exoribonucleases / chemistry
  • Exoribonucleases / genetics
  • Exoribonucleases / metabolism*
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Models, Molecular
  • Polyadenylation
  • Polyribonucleotide Nucleotidyltransferase / chemistry
  • Polyribonucleotide Nucleotidyltransferase / metabolism
  • RNA / genetics
  • RNA / metabolism*
  • RNA Precursors / genetics
  • RNA Precursors / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA Stability

Substances

  • Archaeal Proteins
  • Fungal Proteins
  • RNA Precursors
  • RNA
  • Polyribonucleotide Nucleotidyltransferase
  • Exoribonucleases