Abstract
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.
MeSH terms
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Animals
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Cholesterol / physiology
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Chromogranins / physiology
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Endocrine System / metabolism
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Golgi Apparatus / physiology
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Hormones / metabolism
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Humans
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Lipids / physiology
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Neurons / metabolism
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Neuropeptides / metabolism
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Protein Processing, Post-Translational
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Secretory Vesicles / chemistry*
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Secretory Vesicles / physiology*
Substances
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Chromogranins
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Hormones
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Lipids
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Neuropeptides
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Cholesterol