Abstract
Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Membrane / chemistry
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Cell Membrane / physiology*
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Feedback, Physiological / physiology*
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / physiology*
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Models, Biological
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Sterols / chemistry
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Sterols / metabolism*
Substances
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Membrane Proteins
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Sterols