Abstract
The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.
MeSH terms
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ADP-Ribosylation Factors / genetics
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ADP-Ribosylation Factors / metabolism*
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Adaptor Proteins, Vesicular Transport / genetics
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Adaptor Proteins, Vesicular Transport / metabolism*
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Animals
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Endosomes / metabolism
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Golgi Apparatus / metabolism*
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Humans
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Molecular Structure
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Protein Structure, Tertiary
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Protein Transport / physiology*
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Receptor, IGF Type 2 / metabolism
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trans-Golgi Network / metabolism*
Substances
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Adaptor Proteins, Vesicular Transport
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Carrier Proteins
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GGA adaptor proteins
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Receptor, IGF Type 2
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ADP-Ribosylation Factors