Abstract
Sam68 is one of the most studied members of the STAR family of RNA-binding proteins since its identification over a decade ago. Since its ascension into prominence, enormous progress has been made to unmask the link between the RNA-binding properties of Sam68 and the regulation of cellular processes including signal transduction, cell cycle regulation and tumorigenesis and RNA biogenesis in general. In this review we provide a detailed description of the functional domains of Sam68 and the possible biological roles that justify its superSTAR status.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Cell Cycle
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Cell Transformation, Neoplastic
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Humans
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Molecular Sequence Data
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Phosphoproteins / genetics
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Phosphoproteins / physiology*
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Protein Structure, Tertiary
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / physiology*
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Sequence Homology, Amino Acid
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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DNA-Binding Proteins
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GAP-associated protein p62
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KHDRBS1 protein, human
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Phosphoproteins
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RNA-Binding Proteins