Abstract
Selenium is important for embryogenesis in vertebrates but little is known about the expression patterns and biological functions of most selenoprotein genes. Taking advantage of the zebrafish model, systematic analysis of selenoprotein gene expression was performed by in situ hybridization on whole-mount embryos at different developmental stages. Twenty-one selenoprotein mRNAs were analyzed and all of them exhibited expression patterns restricted to specific tissues. Moreover, we demonstrated that highly similar selenoprotein paralogs were expressed within distinct territories. Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Gene Expression Regulation, Developmental
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In Situ Hybridization
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Molecular Sequence Data
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Proteins / genetics*
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Proteins / metabolism
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RNA Probes
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RNA, Messenger / metabolism
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Selenoproteins
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Tissue Distribution
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Zebrafish / embryology*
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Zebrafish Proteins
Substances
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Proteins
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RNA Probes
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RNA, Messenger
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Selenoproteins
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Zebrafish Proteins
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selenop protein, zebrafish
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selenop2 protein, zebrafish
Associated data
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GENBANK/AF322071
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GENBANK/AF322072
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GENBANK/AY216582
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GENBANK/AY216583
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GENBANK/AY216584
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GENBANK/AY216585
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GENBANK/AY216586
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GENBANK/AY216587
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GENBANK/AY216588
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GENBANK/AY216589
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GENBANK/AY216590
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GENBANK/AY216591
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GENBANK/AY221257
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GENBANK/AY221258
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GENBANK/AY221259
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GENBANK/AY221260
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GENBANK/AY221261
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GENBANK/AY221262
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GENBANK/AY221263
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GENBANK/AY221264
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GENBANK/AY221265