Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

Alan Ho; Steven F Dowdy

doi:10.1016/s0959-437x(01)00263-5

Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

Curr Opin Genet Dev. 2002 Feb;12(1):47-52. doi: 10.1016/s0959-437x(01)00263-5.

Authors

Alan Ho¹, Steven F Dowdy

Affiliation

¹ Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD, 9500 Gilman Drive, La Jolla, California 92093-0686, USA.

PMID: 11790554
DOI: 10.1016/s0959-437x(01)00263-5

Abstract

Progression of resting quiescent G(0) cells into early G(1) and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G(0) to early G(1) transition and metabolism to neoplastic cells.

Publication types

Review

MeSH terms

Animals
Cyclin-Dependent Kinases / antagonists & inhibitors
Cyclins / metabolism
G1 Phase*
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor / physiology*
Humans
Neoplasms / genetics
Neoplasms / metabolism
Oncogenes / physiology*
Resting Phase, Cell Cycle
Retinoblastoma Protein / metabolism
Transcription, Genetic

Substances

Cyclins
Retinoblastoma Protein
Cyclin-Dependent Kinases