Abstract
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?
MeSH terms
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Activating Transcription Factor 1
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Alternative Splicing
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Animals
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Binding Sites
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Cyclic AMP / physiology
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Cyclic AMP Response Element Modulator
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Cyclic AMP Response Element-Binding Protein / chemistry
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Cyclic AMP Response Element-Binding Protein / genetics
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Cyclic AMP Response Element-Binding Protein / physiology*
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Cyclic AMP-Dependent Protein Kinases / physiology
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DNA Methylation
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Gene Expression Regulation / physiology*
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Gene Products, tax / physiology
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Growth Substances / physiology
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Human T-lymphotropic virus 1 / genetics
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Leucine Zippers
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Macromolecular Substances
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Mice
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Mice, Knockout
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Mice, Transgenic
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Models, Genetic
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Models, Molecular
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Multigene Family
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Nuclear Proteins / physiology
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Phosphorylation
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Protein Conformation
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Protein Processing, Post-Translational
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Regulatory Sequences, Nucleic Acid
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Repressor Proteins*
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Second Messenger Systems / physiology
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Stress, Physiological / genetics
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Stress, Physiological / metabolism
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Trans-Activators / physiology
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Transcription Factors / physiology
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Transcription, Genetic*
Substances
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Activating Transcription Factor 1
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Atf1 protein, mouse
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins
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Gene Products, tax
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Growth Substances
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Macromolecular Substances
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Nuclear Proteins
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Repressor Proteins
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Trans-Activators
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Transcription Factors
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Cyclic AMP Response Element Modulator
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases