Abstract
Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy balance systems, these factors provide potential new targets for therapeutic intervention in metabolic diseases, such as obesity and type 2 diabetes mellitus.
MeSH terms
-
Adipose Tissue / embryology*
-
Adipose Tissue / metabolism
-
Adipose Tissue, Brown / embryology
-
Adipose Tissue, Brown / metabolism
-
Animals
-
CCAAT-Enhancer-Binding Proteins
-
Cell Differentiation
-
DNA-Binding Proteins / metabolism
-
DNA-Binding Proteins / physiology
-
Diabetes Mellitus / metabolism
-
Humans
-
Mice
-
Nuclear Proteins / metabolism
-
Nuclear Proteins / physiology
-
Obesity / metabolism
-
Receptors, Cytoplasmic and Nuclear / metabolism
-
Receptors, Cytoplasmic and Nuclear / physiology
-
Transcription Factors / metabolism
-
Transcription Factors / physiology
-
Transcription, Genetic*
Substances
-
CCAAT-Enhancer-Binding Proteins
-
DNA-Binding Proteins
-
Nuclear Proteins
-
Receptors, Cytoplasmic and Nuclear
-
Transcription Factors