Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis
Abstract
:1. Introduction
2. The Gas6/TAM Receptors System
3. Gas6/TAM and Lung Fibrosis
4. Gas6/TAM and Liver Fibrosis
5. Gas6/TAM and Cardiovascular Remodeling
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
APAP | Acetaminophen |
APCs | Antigen presenting cells |
Bg | Beige mutation |
CVDs | Cardiovascular diseases |
ECM | Extracellular matrix |
FDA | Food and Drug Administration |
Gas6 | Growth arrest-specific 6 |
HCV | Hepatitis C virus |
HSCs | Hepatic stellate cells |
IFN | Interferon |
ILDs | Interstitial lung diseases |
IPF | Idiopathic pulmonary fibrosis |
I/R | Ischemia/reperfusion |
KO | Knock-out |
MFBs | Myofibroblastic cells |
NAFLD | Non-alcoholic fatty liver disease |
ProS | Protein S |
SCID | Severe combined immunodeficiency |
TAM | Tyro3, Axl, MerTK |
TGF-β | Transforming growth factor beta |
TLR | Toll-like receptor |
VSMCs | Vascular smooth muscle cells |
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Bellan, M.; Cittone, M.G.; Tonello, S.; Rigamonti, C.; Castello, L.M.; Gavelli, F.; Pirisi, M.; Sainaghi, P.P. Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis. Int. J. Mol. Sci. 2019, 20, 5070. https://doi.org/10.3390/ijms20205070
Bellan M, Cittone MG, Tonello S, Rigamonti C, Castello LM, Gavelli F, Pirisi M, Sainaghi PP. Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis. International Journal of Molecular Sciences. 2019; 20(20):5070. https://doi.org/10.3390/ijms20205070
Chicago/Turabian StyleBellan, Mattia, Micol Giulia Cittone, Stelvio Tonello, Cristina Rigamonti, Luigi Mario Castello, Francesco Gavelli, Mario Pirisi, and Pier Paolo Sainaghi. 2019. "Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis" International Journal of Molecular Sciences 20, no. 20: 5070. https://doi.org/10.3390/ijms20205070