Abstract
The following review was constructed as a concept paper based on a recent workshop on neurodegenerative disease sponsored by the National Institute on Aging (NIA), the American Geriatric Society (AGS), and the John A. Hartford Foundation. The meeting was entitled “Thinking, moving and feeling: Common underlying mechanisms? 4th Annual Bedside-to-Bench Conference” and had the purpose to connect current basic and clinical findings on common brainrelated alterations occurring with aging such as depression, movement disorders, and cognitive decline. Many prominent researchers expressed their opinion on aging and it was revealed that age-related brain dysfunction of any kind seems to share several risk factors and/or pathways. But can something be done to actively achieve “successful aging”? In this review, based largely on the workshop and current literature, we have summarized some of the current theories for depression, movement and cognitive impairment with aging, as well as potential preventive measures. We have also summarized the emerging need for relevant animal models and how these could be developed and utilized.
Keywords: Neurodegeneration, memory, cognitive impairment, movement disorders, age-related depression, oxidative stress, neuroinflammation
Current Aging Science
Title: Mood, Memory and Movement: An Age-Related Neurodegenerative Complex?
Volume: 1 Issue: 2
Author(s): Ann-Charlotte Granholm, Heather Boger and Marina E. Emborg
Affiliation:
Keywords: Neurodegeneration, memory, cognitive impairment, movement disorders, age-related depression, oxidative stress, neuroinflammation
Abstract: The following review was constructed as a concept paper based on a recent workshop on neurodegenerative disease sponsored by the National Institute on Aging (NIA), the American Geriatric Society (AGS), and the John A. Hartford Foundation. The meeting was entitled “Thinking, moving and feeling: Common underlying mechanisms? 4th Annual Bedside-to-Bench Conference” and had the purpose to connect current basic and clinical findings on common brainrelated alterations occurring with aging such as depression, movement disorders, and cognitive decline. Many prominent researchers expressed their opinion on aging and it was revealed that age-related brain dysfunction of any kind seems to share several risk factors and/or pathways. But can something be done to actively achieve “successful aging”? In this review, based largely on the workshop and current literature, we have summarized some of the current theories for depression, movement and cognitive impairment with aging, as well as potential preventive measures. We have also summarized the emerging need for relevant animal models and how these could be developed and utilized.
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Cite this article as:
Granholm Ann-Charlotte, Boger Heather and Emborg E. Marina, Mood, Memory and Movement: An Age-Related Neurodegenerative Complex?, Current Aging Science 2008; 1 (2) . https://dx.doi.org/10.2174/1874609810801020133
DOI https://dx.doi.org/10.2174/1874609810801020133 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
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