Abstract
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings.
Keywords: Religious Orders Study, Dementia, Alzheimer's Disease, Cognitive Function, Epidemiology, Clinical-pathologic Study, Neuropathology, Cohort
Current Alzheimer Research
Title:Overview and Findings from the Religious Orders Study
Volume: 9 Issue: 6
Author(s): David A. Bennett, Julie A. Schneider, Zoe Arvanitakis and Robert S. Wilson
Affiliation:
Keywords: Religious Orders Study, Dementia, Alzheimer's Disease, Cognitive Function, Epidemiology, Clinical-pathologic Study, Neuropathology, Cohort
Abstract: The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings.
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Cite this article as:
A. Bennett David, A. Schneider Julie, Arvanitakis Zoe and S. Wilson Robert, Overview and Findings from the Religious Orders Study, Current Alzheimer Research 2012; 9 (6) . https://dx.doi.org/10.2174/156720512801322573
DOI https://dx.doi.org/10.2174/156720512801322573 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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