Role of MafB in macrophages

Michito Hamada; Yuki Tsunakawa; Hyojung Jeon; Manoj Kumar Yadav; Satoru Takahashi

doi:10.1538/expanim.19-0076

Young Investigator Award

Role of MafB in macrophages

Michito Hamada, Yuki Tsunakawa, Hyojung Jeon, Manoj Kumar Yadav, Satoru Takahashi

Author information

Michito Hamada
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Yuki Tsunakawa
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Hyojung Jeon
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Manoj Kumar Yadav
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Satoru Takahashi
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan

Keywords: homeostasis, large Maf family, macrophage, MafB, transcription factor

JOURNAL OPEN ACCESS

2020 Volume 69 Issue 1 Pages 1-10

DOI https://doi.org/10.1538/expanim.19-0076

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Abstract

The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases.

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