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Licensed Unlicensed Requires Authentication Published by De Gruyter September 1, 2012

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections

  • Anke Ohler EMAIL logo and Christoph Becker-Pauly
From the journal Biological Chemistry

Abstract

Proteolytic enzymes are involved in almost all biological processes reflecting their importance in health and disease. The human genome contains nearly 600 protease-encoding genes forming more than 2% of the total human proteome. The serine proteases, with about 180 members, built the oldest and second largest family of human proteases. Ten years ago, a novel serine protease family named the type II transmembrane family (TTSP) was identified. This minireview summarizes the up-to-date knowledge about the still growing TTSPs, particularly focusing on the pathophysiological functions of the family member type II transmembrane serine protease (TMPRSS) 4. Recent studies provided important data on TMPRSS4 activity associated with the spreading of influenza viruses, mediated by the cleavage of hemagglutinin. Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4, though being a possible diagnostic marker. However, to benefit from TMPRSS4 as a therapeutic target, more data concerning its physiological relevance are needed, as done by a specific morpholino knockdown in zebrafish embryos.


Corresponding author

Received: 2012-3-18
Accepted: 2012-5-14
Published Online: 2012-09-01
Published in Print: 2012-09-01

©2012 by Walter de Gruyter Berlin Boston

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