Gastroenterology

Gastroenterology

Volume 142, Issue 4, April 2012, Pages 730-733.e9
Gastroenterology

Original Research
Brief Report
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

https://doi.org/10.1053/j.gastro.2011.12.042Get rights and content

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms—the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.

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Acknowledgments

The authors thank Ms Bona Kim for providing the pancreatic intraepithelial neoplasm illustration (Figure 2).

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M.K., H.M., and J.W. contributed equally to this work.

Conflicts of interest The authors disclose no conflicts.

Funding This work was supported by National Institutes of Health grants (CA62924, R01CA97075, R01CA120432, RC2CA148376, and P01CA134292), the Stringer Foundation, the Michael Rolfe Foundation, the Lustgarten Foundation for pancreatic cancer research, and German Cancer Aid (Deutsche Krebshilfe e.V.).

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