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Role of Src expression and activation in human cancer

Oncogene volume 19, pages 5636–5642 (2000)Cite this article

Abstract

Since the original identification of a transmissible agent responsible for the development of tumors in chickens, now known to be a retrovirus encoding the v-src gene, significant progress has been made in defining the potential functions of its human homolog, SRC. The product of the human SRC gene, c-Src, is found to be over-expressed and highly activated in a wide variety of human cancers. The relationship between Src activation and cancer progression appears to be significant. Moreover, Src may have an influence on the development of the metastatic phenotype. This review discusses the data supporting a role for c-Src as a critical component of the signal transduction pathways that control cancer cell development and growth, and provides the rationale for targeting Src in drug discovery efforts.

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References

  • Abts H, Jucker M, Diehl V and Tesch H. . 1991 Leuk. Res. 15: 987–997.

  • Biscardi J, Tice D and Parsons S. . 1999a Advances in Cancer Research 76: 61–119.

  • Biscardi JS, Belsches AP and Parsons SJ. . 1998 Mol. Carcinog. 21: 261–272.

  • Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH and Parsons SJ. . 1999b J. Biol. Chem. 274: 8335–8343.

  • Bjelfman C, Hedborg F, Johansson I, Nordenskjold M and Pahlman S. . 1990 Cancer Res. 50: 6908–6914.

  • Bjorge JD, O'Connor TJ and Fujita DJ. . 1996 Biochem. Cell Biol. 74: 477–484.

  • Bolen J, Veillette A, Schwartz A, DeSeau V and Rosen N. . 1987a Proc. Natl. Acad. Sci. USA 84: 2251–2255.

  • Bolen J, Veillette A, Schwartz A, Deseau V and Rosen N. . 1987b Oncogene Res. 1: 149–168.

  • Bolen JB, Rosen N and Israel MA. . 1985 Proc. Natl. Acad. Sci. USA 82: 7275–7279.

  • Bowman T, Garcia R, Turkson J and Jove R. . 2000 Oncogene 19: 2474–2488.

  • Bromberg JF, Horvath CM, Besser D, Lathem WW and Darnell Jr JE. . 1998 Mol. Cell Biol. 18: 2553–2558.

  • Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell Jr JE. . 1999 Cell 98: 295–303.

  • Brown M and Cooper J. . 1996 Biochim. Biophys. Acta. 1287: 121–149.

  • Brummer J, Neumaier M, Gopfert C and Wagener C. . 1995 Oncogene 11: 1649–1655.

  • Budde RJ, Ke S and Levin VA. . 1994 Cancer Biochem. Biophys. 14: 171–175.

  • Cartwright C, Coad C and Egbert B. . 1994 J. Clin. Invest. 93: 509–515.

  • Cartwright C, Kamps M, Meisler A, Pipas J and Eckhart W. . 1989 J. Clin. Invest. 83: 2025–2033.

  • Cartwright C, Meisler A and Eckhart W. . 1990 Proc. Natl. Acad. Sci. USA 87: 558–562.

  • Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernandez-Luna JL, Nunez G, Dalton WS and Jove R. . 1999 Immunity 10: 105–115.

  • Courtneidge SA, Fumagalli S, Koegl M, Superti-Furga G and Twamley-Stein GM. . 1993 Dev. Suppl. 57–64.

  • Czernilofsky AP, Levinson AD, Varmus HE, Bishop JM, Tischer E and Goodman HM. . 1980 Nature 287: 198–203.

  • Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW and Pendergast AM. . 1998 Genes Dev. 12: 1415–1424.

  • Daigo Y, Furukawa Y, Kawasoe T, Ishiguro H, Fujita M, Sugai S, Nakamori S, Liefers GJ, Tollenaar RA, van de Velde CJ and Nakamura Y. . 1999 Cancer Res. 59: 4222–4224.

  • Danhauser-Riedl S, Warmuth M, Druker BJ, Emmerich B and Hallek M. . 1996 Cancer Res. 56: 3589–3596.

  • Egan C, Pang A, Durda D, Cheng HC, Wang JH and Fujita DJ. . 1999 Oncogene 18: 1227–1237.

  • Fleming RY, Ellis LM, Parikh NU, Liu W, Staley CA and Gallick GE. . 1997 Surgery 122: 501–507.

  • Flossmann-Kast BB, Jehle PM, Hoeflich A, Adler G and Lutz MP. . 1998 Cancer Res. 58: 3551–3554.

  • Genda T, Sakamoto M, Ichida T, Asakura H and Hirohashi S. . 2000 Lab. Invest. 80: 387–394.

  • Guy C, Muthuswamy S, Cardiff R, Soriano P and Muller W. . 1994 Genes Dev. 8: 23–32.

  • Haas M, Askari A and Xie Z. . 2000 J. Biol. Chem. (in press).

  • Hamaguchi M, Matsuyoshi N, Ohnishi Y, Gotoh B, Takeichi M and Nagai Y. . 1993 EMBO. J. 12: 307–314.

  • Irby R, Mao W, Coppola D, Jove R, Gamero A, Cuthbertson D, Fujita DJ and Yeatman TJ. . 1997 Cell Growth Differ. 8: 1287–1295.

  • Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, Trudeau W, Kari R, Fujita DJ, Jove R and Yeatman TJ. . 1999 Nat. Genet. 21: 187–190.

  • Jacobs C and Rubsamen H. . 1983 Cancer Res. 43: 1696–1702.

  • Jove R and Hanafusa H. . 1987 Annu. Rev. Cell Biol. 3: 31–56.

  • Karni R, Jove R and Levitzki A. . 1999 Oncogene 18: 4654–4662.

  • Kumble S, Omary MB, Cartwright CA and Triadafilopoulos G. . 1997 Gastroenterology 112: 348–356.

  • LaVallee TM, Prudovsky IA, McMahon GA, Hu X and Maciag T. . 1998 J. Cell Biol. 141: 1647–1658.

  • Levitzki A. . 1996 Anticancer Drug Des. 11: 175–182.

  • Luttrell D, Lee A, Lansing T, Crosby R, Jung K, Willard D, Luther M, Rodriguez M, Berman J and Gilmer T. . 1994 Proc. Natl. Acad. Sci. USA 91: 83–87.

  • Lutz MP, Esser IB, Flossmann-Kast BB, Vogelmann R, Luhrs H, Friess H, Buchler MW and Adler G. . 1998 Biochem. Biophys. Res. Commun. 243: 503–508.

  • Maa M, Leu T, McCarley D, Schatzman R and Parsons S. . 1995 Proc. Natl. Acad. Sci. USA 92: 6981–6985.

  • Machida K, Matsuda S, Yamaki K, Senga T, Thant AA, Kurata H, Miyazaki K, Hayashi K, Okuda T, Kitamura T, Hayakawa T and Hamaguchi M. . 2000 Oncogene 19: 1710–1718.

  • Mao W, Irby R, Copolla D, Fu L, Wloch M, Turner J, Yu H, Garcia R, Jove R and Yeatman T. . 1997 Oncogene 15: 3083–3090.

  • Masaki T, Okada M, Shiratori Y, Rengifo W, Matsumoto K, Maeda S, Kato N, Kanai F, Komatsu Y, Nishioka M and Omata M. . 1998 Hepatology 27: 1257–1264.

  • Masaki T, Okada M, Tokuda M, Shiratori Y, Hatase O, Shirai M, Nishioka M and Omata M. . 1999 Hepatology 29: 379–384.

  • Masaki T, Shiratori Y, Okada H, Nishioka M, Taniguchi K, Hatanaka Y and Omata M. . 2000 Am. J. Gastroenterol. 95: 837–838.

  • Mazurenko NN, Kogan EA, Zborovskaya IB and Kisseljov FL. . 1992 Eur. J. Cancer 28: 372–377.

  • Munshi N, Groopman JE, Gill PS and Ganju RK. . 2000 J. Immunol. 164: 1169–1174.

  • Muthuswamy S and Muller W. . 1994 Adv. Cancer Res. 64: 111–123.

  • Muthuswamy S, Siegel P, Dankort D, Webster M and Muller W. . 1994 Mol. Cell. Biol. 14: 735–743.

  • Odajima J, Matsumura I, Sonoyama J, Daino H, Kawasaki A, Tanaka H, Inohara N, Kitamura T, Downward J, Nakajima K, Hirano T and Kanakura Y. . 2000 J. Biol. Chem. (in press).

  • Ottenhoff-Kalff A, Rijksen G, van BE, Hennipman A, Michels A and Staal G. . 1992 Cancer Res. 52: 4773–4778.

  • Park J and Cartwright C. . 1995 Mol. Cell. Biol. 15: 2374–2382.

  • Park J, Meisler A and Cartwright C. . 1993 Oncogene 8: 2627–2635.

  • Pena SV, Melhem MF, Meisler AI and Cartwright CA. . 1995 Gastroenterology 108: 117–124.

  • Peng Z and Cartwright C. . 1995 Oncogene 11: 1955–1962.

  • Rahimi N, Hung W, Tremblay E, Saulnier R and Elliott B. . 1998 J. Biol. Chem. 273: 33714–33721.

  • Roginskaya V, Zuo S, Caudell E, Nambudiri G, Kraker AJ and Corey SJ. . 1999 Leukemia 13: 855–861.

  • Rosen N, Bolen JB, Schwartz AM, Cohen P, DeSeau V and Israel MA. . 1986 J. Biol. Chem. 261: 13754–13759.

  • Rous P. . 1911 J. Exp. Med. 13: 397–411.

  • Shimakage M, Kawahara K, Kikkawa N, Sasagawa T, Yutsudo M and Inoue H. . 2000 Int. J. Cancer 87: 5–11.

  • Staley C, Parikh N and Gallick G. . 1997 Cell Growth & Differ. 8: 269–274.

  • Stehelin D, Varmus H, Bishop J and Vogt P. . 1976 Nature 260: 170–173.

  • Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao HY, Nagai Y and Takagi H. . 1991 Jpn. J. Cancer Res. 82: 1428–1435.

  • Talamonti MA, Roh MS, Curley SA and Gallick GE. . 1991 J. Clin. Invest. 91: 53.

  • Termuhlen PM, Curley SA, Talamonti MS, Saboorian MH and Gallick GE. . 1993 J. Surg. Res. 54.

  • Thomas SM and Brugge JS. . 1997 Annu. Rev. Cell. Dev. Biol. 13: 513–609.

  • Tice DA, Biscardi JS, Nickles AL and Parsons SJ. . 1999 Proc. Natl. Acad. Sci. USA 96: 1415–1420.

  • Tokumitsu Y, Nakano S, Ueno H and Niho Y. . 2000 J. Cell. Physiol. 183: 221–227.

  • Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP and Jove R. . 1998 Mol. Cell. Biol. 18: 2545–2552.

  • Verbeek BS, Vroom TM, Adriaansen-Slot SS, Ottenhoff-Kalff AE, Geertzema JG, Hennipman A and Rijksen G. . 1996 J. Pathol. 180: 383–388.

  • Visser CJ, Rijksen G, Woutersen RA and De Weger RA. . 1996 Lab. Invest. 74: 2–11.

  • Wang NM, Yeh KT, Tsai CH, Chen SJ and Chang JG. . 2000 Cancer Lett. 150: 201–204.

  • Weber T, Steele G and Summerhayes I. . 1992 J. Clin. Invest. 90: 815–821.

  • Wen X, Lin HH, Shih HM, Kung HJ and Ann DK. . 1999 J. Biol. Chem. 274: 38204–38210.

  • Wiener JR, Nakano K, Kruzelock RP, Bucana CD, Bast Jr RC and Gallick GE. . 1999 Clin. Cancer Res. 5: 2164–2170.

  • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J and Jove R. . 1995 Science 269: 81–83.

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Acknowledgements

We thank R Jove for his kind reading of the manuscript. This work was supported by a grant from the American Cancer Society ACS RPG-99-099-01.

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  1. Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, 33612, Florida, FL, USA

    Rosalyn B Irby & Timothy J Yeatman

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Irby, R., Yeatman, T. Role of Src expression and activation in human cancer. Oncogene 19, 5636–5642 (2000). https://doi.org/10.1038/sj.onc.1203912

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