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GPNMB: expanding the code for liver–fat communication

Nature Metabolism volume 1, pages 507–508 (2019)Cite this article

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Interorgan communication is emerging as a critical contributor to nutrient and energy homeostasis. A new study has identified a secreted liver factor that stimulates lipid synthesis in white adipose tissue and exacerbates obesity and insulin resistance.

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Fig. 1: A novel hepatokine mediates hepatic–adipose endocrine signalling.

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Authors and Affiliations

  1. Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, MI, USA

    Henry Kuang & Jiandie D. Lin

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  1. Henry Kuang
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  2. Jiandie D. Lin
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Correspondence to Jiandie D. Lin.

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Kuang, H., Lin, J.D. GPNMB: expanding the code for liver–fat communication. Nat Metab 1, 507–508 (2019). https://doi.org/10.1038/s42255-019-0069-0

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