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Chromatin replication and epigenetic cell memory

Nature Cell Biology volume 22, pages 361–371 (2020)Cite this article

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Abstract

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.

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Fig. 1: Distinct pathways for parental histone recycling during DNA replication.
Fig. 2: Genome-wide methods for studying chromatin replication.
Fig. 3: Epigenome propagation mechanisms.

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Acknowledgements

K.R.S.-M. is supported by a postdoctoral fellowship from the Lundbeck Foundation and a Marie Curie Individual Fellowship (MSCA-IF-2016 no. 747332). Research in the Groth laboratory is supported by the Lundbeck Foundation (R198-2015-269), the European Research Council (ERC CoG no. 724436), Independent Research Fund Denmark (7016-00042B; 4092-00404B), the Novo Nordisk Foundation (NNF14CC0001; NNF14OC0012839), the NEYE foundation and the Danish Cancer Society.

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  1. Nataliya Petryk

    Present address: Epigenetics and Cell Fate, UMR7216 CNRS, University of Paris, Paris, France

Authors and Affiliations

  1. The Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark

    Kathleen R. Stewart-Morgan & Anja Groth

  2. Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

    Kathleen R. Stewart-Morgan, Nataliya Petryk & Anja Groth

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K.R.S.-M., N.P. and A.G. conceived, prepared figures for and wrote the manuscript.

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Correspondence to Anja Groth.

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A.G. is CSO and co-founder of Ankrin Therapeutics.

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Stewart-Morgan, K.R., Petryk, N. & Groth, A. Chromatin replication and epigenetic cell memory. Nat Cell Biol 22, 361–371 (2020). https://doi.org/10.1038/s41556-020-0487-y

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