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Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Nature Reviews Molecular Cell Biology volume 13, pages 483–488 (2012)Cite this article

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Abstract

During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.

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Figure 1: The major stages from cytokinesis to abscission.
Figure 2: Multiple pathways are required to accomplish abscission.
Figure 3: The mitotic kinases PLK1 and Aurora B regulate cytokinesis progression and coordination.

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Acknowledgements

The authors apologize to colleagues whose work is not discussed or cited owing to space constraints. The authors are particularly grateful to A. Bright and S. Redick from the Doxsey laboratory for critical reading of the manuscript and thoughtful discussions. Work in the Doxsey laboratory is supported by the US National Institutes of Health (NIH), the Ellison Medical Foundation, the W. M. Keck Foundation and the US Department of Defense.

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  1. Chun-Ting Chen, Heidi Hehnly and Stephen J. Doxsey are at the Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA,

    Chun-Ting Chen, Heidi Hehnly & Stephen J. Doxsey

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Chen, CT., Hehnly, H. & Doxsey, S. Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission. Nat Rev Mol Cell Biol 13, 483–488 (2012). https://doi.org/10.1038/nrm3395

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