Adipocytes and scar tissue form during skeletal muscle degeneration. Two new studies reveal that adipocytes and fibroblasts in skeletal muscle derive from a population of bipotent progenitors that reside within muscle, but are not derived from the muscle lineage. These progenitor cells also have a surprising role in stimulating the restoration of muscle mass during regeneration.
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Rodeheffer, M. Tipping the scale: muscle versus fat. Nat Cell Biol 12, 102–104 (2010). https://doi.org/10.1038/ncb0210-102
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DOI: https://doi.org/10.1038/ncb0210-102
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