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Identification of a cryptic nucleolar-localization signal in MDM2

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Figure 1: Nucleolar-localization signal in MDM2.
Figure 2: Subnuclear localization of p14ARF with MDM2 mutants.
Figure 3: Function of the MDM2 NoLS.

References

  1. Bates, S. & Vousden, K. H. Cell. Mol. Life Sci. 55, 28–37 (1999).

    Article  CAS  Google Scholar 

  2. Kubbutat, M. H. G. & Vousden, K. H. Mol. Med. Today 4, 250–256 ( 1998).

    Article  CAS  Google Scholar 

  3. Sherr, C. J. Genes Dev. 12, 2984–2991 (1998).

    Article  CAS  Google Scholar 

  4. Kamijo, T. et al. Proc. Natl Acad. Sci. USA 95, 8292– 8297 (1998).

    Article  CAS  Google Scholar 

  5. Pomerantz, J. et al. Cell 92, 713– 723 (1998).

    Article  CAS  Google Scholar 

  6. Stott, F. et al. EMBO J. 17,5001–5014 (1998).

  7. Zhang, Y., Xiong, Y. & Yarbrough, W. G. Cell 92,725–734 (1998).

  8. Honda, R. & Yasuda, H. EMBO J. 18, 22–27 (1999).

    Article  CAS  Google Scholar 

  9. Tao, W. & Levine, A. J. Proc. Natl Acad. Sci. USA 96, 6937–6941 (1999).

    Article  CAS  Google Scholar 

  10. Zhang, Y. & Xiong, Y. Mol. Cell 3, 579–591 (1999).

    Article  CAS  Google Scholar 

  11. Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J. & Bar-Sagi, D. Nature Cell Biol. 1 , 20–26 (1999).

    Article  CAS  Google Scholar 

  12. Kubbutat, M. H. G., Ludwig, R. L., Levine, A. J. & Vousden, K. H. Cell Growth Differ. 10, 87–92 (1999).

    CAS  PubMed  Google Scholar 

  13. Chen, J., Lin, J. & Levine, A.J. Mol. Med. 1, 142– 152 (1995).

    Article  CAS  Google Scholar 

  14. Böttger, A. et al. Curr. Biol. 7, 860– 869 (1997).

    Article  Google Scholar 

  15. Weber, J. D. et al. Mol. Cell. Biol. (in the press).

  16. Bates, S. et al. Nature 395, 124–125 (1998).

    Article  CAS  Google Scholar 

  17. Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H. & Weissman, A. M. J. Biol. Chem. (in the press).

Download references

Acknowledgements

We thank C. Sherr, J. Weber and G. Peters for advice and sharing unpublished results.

Correspondence and requests for materials should be addressed to K.H.V.

Supplementary information is available on Nature Cell Biology’s World-Wide Web site (http://www.nature.com/ncb) or as paper copy from the London editorial office of Nature Cell Biology.

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Correspondence to Karen H. Vousden.

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Lohrum, M., Ashcroft, M., Kubbutat, M. et al. Identification of a cryptic nucleolar-localization signal in MDM2 . Nat Cell Biol 2, 179–181 (2000). https://doi.org/10.1038/35004057

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