Abstract
The genes encoding a γδ T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the Tla locus have been inserted into the mouse germ line. In mice that do not express the Tla-encoded determinant, transgenic γδ T cells are a functional component of the CD4~CD8~ 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the Tla-encoded determinant, there are no transgenic γδ T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic γδ T-cell receptor.
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Dent, A., Matis, L., Hooshmand, F. et al. Self-reactive γδ T cells are eliminated in the thymus. Nature 343, 714–719 (1990). https://doi.org/10.1038/343714a0
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DOI: https://doi.org/10.1038/343714a0
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