Abstract
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochon-dria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.
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Ostermann, J., Horwich, A., Neupert, W. et al. Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature 341, 125–130 (1989). https://doi.org/10.1038/341125a0
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DOI: https://doi.org/10.1038/341125a0
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