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The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

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Figure 1: Exonuclease activity of wild-type WRN and the N333 fragment.
Figure 2: Helicase and exonuclease activities of wild-type and mutant WRN proteins.

References

  1. Martin, G.M. Birth Defects 14, 5–39 ( 1978).

    CAS  PubMed  Google Scholar 

  2. Goto, M. Mech. Ageing Dev. 98, 239–254 (1997).

    Article  CAS  Google Scholar 

  3. Martin, G.M., Sprague, C.A. & Epstein, C.J. Lab. Invest. 23, 86– 92 (1970).

    CAS  PubMed  Google Scholar 

  4. Salk, D., Bryant, E., Hoehn, H., Johnston, P. & Martin, G.M. Adv. Exp. Bio. Med. 190, 305–311 (1985).

    Article  CAS  Google Scholar 

  5. Fukuchi, K., Martin, G.M. & Monnat, R.J. Proc. Natl Acad. Sci. USA 86, 5893–5897 (1989).

    Article  CAS  Google Scholar 

  6. Cheng, R.Z., Murano, S., Kurz, B. & Shmookler-Reis, R.J. Mutat. Res. 237, 259–269 ( 1990).

    Article  CAS  Google Scholar 

  7. Yu, C.E. et al. Science 272, 258–262 (1996).

    Article  CAS  Google Scholar 

  8. German, J. Medicine 72, 393–406 ( 1993).

    Article  CAS  Google Scholar 

  9. Main, I.S. Nucleic Acids Res. 25, 3187–3195 (1997).

    Article  Google Scholar 

  10. Mushegian, A.R., Bassett, D.E. Jr, Boguski, M.S., Bork, P., & Koonin, E.V. Proc. Natl Acad. Sci. USA 94, 5831–5836 ( 1997).

    Article  CAS  Google Scholar 

  11. Gray, M.D. et al. Nature Genet. 17, 100– 103 (1997).

    Article  CAS  Google Scholar 

  12. Linn, S.M., Lloyd, R.S. & Roberts, R.T. Nucleases (Cold Spring Harbor Laboratory Press, New York, 1993).

  13. Yamagata, K. et al. Proc. Natl Acad. Sci. USA 95, 8733– 8738 (1998).

    Article  CAS  Google Scholar 

  14. Ogburn, C.E. et al. Hum. Genet. 101, 121– 125 (1997).

    Article  CAS  Google Scholar 

  15. Yan, H., Chen, C.-Y., Kobayashi, R. & Newport, J. Nature Genet. 19, 375–378 (1998).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank S. Linn for valuable discussions and H. Asahara for technical advice. This work was supported by the National Institute on Ageing (grants AG11658 (J.C.); AG05776 (S.H.); AG14446 (J.O.)) and Department of Energy under contract DE-AC0376SF00098 to the University of California.

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Correspondence to Judith Campisi.

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Huang, S., Li, B., Gray, M. et al. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat Genet 20, 114–116 (1998). https://doi.org/10.1038/2410

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