Abstract
THAT amino-acids can inhibit growth of certain bacteria has been known for some time1. Thus Gladstone2 showed that several strains of Bacillus anthracis which grew well on a synthetic amino-acid medium failed to grow when leucine or valine was added in concentrations as low as 1 µgm. per ml.; but a very small amount of leucine could abolish the inhibitory effect of valine and vice versa. A similar, though less marked, relationship was shown to exist between serine and threonine.
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References
Gordon, J., and McLeod, J. W., J. Path. Bact., 29, 12 (1926).
Gladstone, G. P., Brit. J. Exp. Path., 20, 189 (1939).
Washburn, M. R., and Niven, C. F., J. Bact., 55, 769 (1948).
Davis, B. D., and Mingioli, E. C., J. Bact., 60, 17 (1950).
Porter, J. R., and Meyers, F. D., Arch. Biochem., 8, 169 (1945).
Kobayashi, Y., Fling, M., and Fon, S. W., J. Biol. Chem., 174, 391 (1945).
Yaw, E. K., and Kakawas, J. C., J. Bact., 63, 263 (1952).
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ROWLEY, D. Inhibition of E. coli Strains by Amino-Acids. Nature 171, 80–81 (1953). https://doi.org/10.1038/171080a0
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DOI: https://doi.org/10.1038/171080a0
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