Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists
A selected set of 1-aryl-7,8-methylenedioxy-2,3-benzodiazepin-4-ones and their analogues were evaluated for their ability to bind the competitive and noncompetitive sites of AMPA receptors as well as glycine/NMDA receptor site.
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Acknowledgements
This work was financially supported by the Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR- COFIN2001), Rome, Italy. We thank Martin J. Pagnozzi, Mary A. Collins and John T. Lazzaro of Pfizer Inc. for excellent technical assistance.
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