Letters to the EditorPENICILLAMINE MAY DETOXIFY COPPER IN WILSON'S DISEASE
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Chelation Therapy: D-Penicillamine
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2018, International Journal of Biochemistry and Cell BiologyHigh spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment
2018, Journal of Trace Elements in Medicine and BiologySpatial investigation of the elemental distribution in Wilson's disease liver after D-penicillamine treatment by LA-ICP-MS
2017, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :This rapidly deteriorating liver status has been suggested to be the result of insufficient copper elimination by DPA in WD patient livers. In fact, massively elevated liver copper levels have been reported in WD patients despite decades of DPA therapy [13]. To investigate the distribution of remaining copper, spatially resolved techniques for elemental bioimaging such as laser ablation-inductively coupled plasma-mass spec-trometry (LA-ICP-MS) offer outstanding characteristics to detect copper within the liver tissue.
Copyright © 1987 Published by Elsevier Ltd.