How Does Helicobacter pylori Cause Mucosal Damage? The Inflammatory Response
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2023, Neurochemistry InternationalBacteria as a double-action sword in cancer
2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :It induces a T helper type 1 (Th1) that is involved in proinflammatory cytokines [IL-1Ī², tumor necrosis factor alpha (TNF-Ī±), and interferon gamma (IFN-Ī³)] secretion. The generation and changes in the cell differentiation, as well as the recurrence of necrosis in the cells, are affected by the alterations in the gastric mucosa [13,14]. The cytotoxin associated gene A (CagA) produce by H. pylori is one of the first bacterial proteins that has been identified for its role in human cancer.
The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression
2014, Advances in Medical SciencesCitation Excerpt :It has been suggested that Helicobacter pylori as a factor of chronic inflammation in the stomach disrupts the balance between gastric epithelial cell proliferation and apoptosis leading to the development of gastric cancer [1ā4].
Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice
2014, GastroenterologyCitation Excerpt :Finally, because the biopsy specimens were not stained with specific immune cell markers, the BMP-positive cells could have represented fibroblasts located in the proximity of the inflammatory infiltrates. One important finding of our study was that BMP signaling specifically targets epithelial but not mesenchymal and immune cells and that induction of BMP signaling in the epithelium leads to inhibition of IL8 production, a chemokine that plays a crucial role in the response of the epithelium to inflammatory stimuli.23ā27,36 The observation that this effect could be seen in both canine primary epithelial cells and in human AGS cells underscores the relevance of these results in gastric pathophysiology.