Trends in Parasitology
Volume 33, Issue 4, April 2017, Pages 257-260
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Type I Interferon in Malaria: A Balancing Act

https://doi.org/10.1016/j.pt.2016.12.010Get rights and content

Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection. Plasmacytoid dendritic cells (pDCs) were identified as the major source of IFN-Is. Here, we integrate the findings and provide a model for the mechanisms involved.

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Acknowledgements

J.P.M. was funded by MRC/DFID Concordat agreement Grant number MR/P000959/1. J.C.H. was supported by NC3Rs grant NC/L000601/1 and Royal Society grants UF120026, RG130034 and CH160018. S.C.W. was supported by NIH/NIAID award U19AI089676-01S1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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