ReviewTargeting stress granules: A novel therapeutic strategy for human diseases
Graphical abstract
Abbreviation
AD
Alzheimer’s disease
ALS
amyotrophic lateral sclerosis
ATF4
activating transcription factor 4
Caprin 1
cell cycle associated protein 1
CK2
Casein kinase 2
DDX3X
DEAD box RNA helicase 3 X-linked
DOX
doxorubicin
eIF2
eukaryotic initiation factor 2
eIF4F
eukaryotic initiation factor 4F
ERK
extracellular signal-regulated kinase
FTD
frontotemporal dementia
FUS/TLS
fused in sarcoma/translocated in liposarcoma
GCN2
general control non-derepressible 2
GCN4
general control non-derepressible 4
G3BP1/2
Ras GTPase-activating protein-binding protein 1 and 2
HDAC
histone deacetylases
HRI
heme-regulated inhibitor
hsp
heat shock protein
JNK
c-Jun N-terminal kinase
LLPS
liquid-liquid phase separation
mRNP
messenger ribonucleoprotein
mTOR
mammalian target of rapamycin
NLRP3
NLR Family, Pyrin Domain Containing Protein 3
N protein
nucleocapsid protein
PAI-1
plasminogen activator inhibitor-1
P-body
processing body
PERK
PKR-like endoplasmatic reticulum kinase
PKR
protein kinase RNA-activated
PTM
post-translational modifications
RBP
RNA-binding protein
ROS
reactive oxygen species
SA
sodium arsenite
SG
stress granule
TDP-43
TAR DNA binding protein 43
TIA-1
T cell restricted intracellular antigen-1
TIAR-2
homolog of human TIA-1 inC. elegans pharyngeal muscles
VCP
valosin-containing protein
4E-BP1
eIF4E-binding protein 1
5-FU
5-fluorouracil
Chemical compounds studied in this article
Bortezomib (PubChem CID: 387447)
E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid (PubChem CID: 16760346)
ISRIB (PubChem CID: 1011240)
Olaparib (PubChem CID: 23725625)
Paclitaxel (PubChem CID: 36314)
PP242 (PubChem CID:135565635)
Psammaplysin F (PubChem CID: 46888580)
Puromycin (PubChem CID: 439530)
Silvestrol (PubChem CID: 11787114)
Sorafenib (PubChem CID: 216239)
Trehalose (PubChem CID: 7427)
5-Fluorouracil (PubChem CID: 3385)
Keywords
eIF2α
G3BP
Microtubule
Post-translational modification
Neurodegenerative disease
Virus infection
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