Neuron
Volume 80, Issue 3, 30 October 2013, Pages 588-601
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Neural Stem Cells: Generating and Regenerating the Brain

https://doi.org/10.1016/j.neuron.2013.10.037Get rights and content
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One of the landmark events of the past 25 years in neuroscience research was the establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a concept that shattered the dogma that the nervous system lacked regenerative power. Stem cells afford the plasticity to generate, repair, and change nervous system function. Combined with reprogramming technology, human somatic cell-derived NSCs and their progeny can model neurological diseases with improved accuracy. As technology advances, we anticipate further important discoveries and novel therapies based on the knowledge and application of these powerful cells.

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