Molecular Cell
Volume 42, Issue 6, 24 June 2011, Pages 794-805
ArticleHuman Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
Under a Creative Commons license
open access
Graphical Abstract
Highlights
► Senataxin is required for pause-dependent Pol II termination in human genes ► R-loops accumulate over G-rich pause regions and are required for termination ► R-loops dependent on transcription, functional poly(A) signal, and pause elements ► Senataxin resolves R-loops to allow Xrn2 to mediate Pol II release from the gene
Cited by (0)
Copyright © 2011 Elsevier Inc.